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Copper is the most common type of conductor due to its good conduc- tivity and ease of working. Matteini,F. A comparison of the distance range matrix 266 Subject Index complexes cation-π and π-π 11 hydrogen-bonded 7 ion-benzene 12 computational methods, pharmacophore modelling 255 computer-assisted drug design 87 computer-assisted molecular modelling (CAMM) 85 computer simulations, biochemical systems 165 CoMSIA method, similarity fields 248 CONCORDprogram 216, 220, 305, 308, Coulomb term 4 Coulson charges 141 Cramer BCDEF data set 384 critical L values 390 Crixivan® 82 cross-validation, leave-one-out 370 crossover, in genetic algorithm 306 crystal structures: proteins 117, 263 CSD (Cambridge structural database) 309 cubane combinatorial library 295 Cu(II) electron transfer, superoxide dismutase 313 conductor-like dielectric continuum conformational 134 170 ff cumulative similarity indices cut-off radius 117 CVFF force field 65 cytidine deaminase inhibitors 321 232, 233 enthalpy 45 entropy 45, 124 flexibility 9, 91, 308 information, encoding sensitivity, EVA descriptor D-optimal design 57 Daphnia magna toxicity, WHIM QSAR 371 database searching 266, 301, 329 DC method 133 SCF method 134 de novo drug design 201 knowledge-based 110 pharmacophore model 267 Debye screening, in AMMP 125 deconvolution of combinatorial libraries 296 DELPHI method 65 density-functional method, path integral method 164 density-functional theory (DFT) 133, 137, 161ff,169 ff and molecular dynamics 161 ff, 169 ff density, molecular 360 descriptors, EVA, see EVA descriptors, WHIM, see WHIM design, see also drug design, d e novo design bioisosteric 280 190, 201 244, 245 space, sampling conformations bioactive 256 characteristic frozen 226 182 215 constrained molecular dynamics contact surface area 46 contacts, non-bonded, in ligand-protein complexes 199 continuous fast multipole method 133 continuum electrostatic theory 24 continuum solvation method, BATCHMIN GBISA 74 contour maps 6 convergence, in genetic algorithm copper-zinc superoxide dismutase CORINAprogram 275, 285 correlation coefficient Pearson 323 307 169 ff Spearman 322-326 corticosteroid binding globulin (CBG) forex pk prize bond results 303 of ligands desipramine desolvation 273ff, 293 affinities 387 Kohonen maps energies 29 DFT, see density-functional theory 161 DHDYM method 261 DHFR, see dihydrofolate reductase dichloroisoproterenol 241, 242 dihydrofolate reductase 233, 240, 241 280 corticosterone, forex pk prize bond results model 276, 279 cosine coefficient, molecular similarity COSMO model 134 404 2 15 392 164 90, 94, 103 and binding energies 87 hu14.
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